MirtazapineD3(Org3770D3;6-AzamianserinD3)是Mirtazapine的氘代物。Mirtazapine是5-HTreceptor受体抑制剂。Mirtazapine是一种有效的具有口服活性去甲肾上腺素能和特异性5-羟色胺抗抑郁试剂(NaSSA)，可阻断5-HT2和5-HT3受体。
货号:ajcx31072
CAS:1216678-68-0
分子式:C17H16D3N3
分子量：268.37
溶解度:DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 15 mg/ml,Ethanol: 15 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

Mirtazapine (intraperitoneal injection; 10-50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score[2]. Animal Model: MeCP2 null mice[2]

[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64. [2]. Kooyman AR, et al. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells.Neuropharmacology. 1994 Mar-Apr;33(3-4):501-7.