MT1是BETbromodomains的化学探针，其对BRD4(1)的IC50值为0.789nM。
货号:ajcx31128
CAS:2060573-82-0
分子式:C54H66Cl2N10O9S2
分子量：1134.2
溶解度:DMSO: 150 mg/mL (132.25 mM); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells[1].

MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].MT1 exhibits terminal t1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1].

[1]. Minoru Tanaka, et al. Design and characterization of bivalent BET inhibitors. Nat Chem Biol. 2016 Dec;12(12):1089-1096.