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Polymyxin B nonapeptide TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Polymyxin B nonapeptide TFA图片
规格:98%
分子量:1533.25
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
PolymyxinBnonapeptideTFA是一种阳离子环肽。PolymyxinBnonapeptideTFA是经酶裂解PolymyxinB而产生的衍生物,与PolymyxinB相比,PolymyxinBnonapeptideTFA毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。
货号:ajcx31318
CAS:2220175-42-6
分子式:C43H74N14O11.5C2HF3O2
分子量:1533.25
溶解度:H2O: 100 mg/mL (65.22 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].


[1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92. [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.