Cefminoxsodium(MT-141)是一种半合成的头霉素，具有广谱的抗菌活性。Cefminoxsodium(MT-141)为前列环素受体(prostacyclinreceptor)和PPARγ的双重激动剂，能够上调cAMP的产生和PTEN的表达，抑制Akt/mTOR信号通路。Cefminoxsodium(MT-141)可抑制肺动脉高压。
货号:ajcx32488
CAS:75498-96-3
分子式:C16H20N7NaO7S3
分子量：541.56
溶解度:H2O: 83.33 mg/mL (153.87 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity[1]. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension[2].

[1]. Inouye S, et al. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. [2]. Xia J, et al. Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134.