Eudesmin ((-)-Eudesmin) 通过抑制 S6K1 信号通路来干扰成脂分化。Eudesmin 具有多种作用，包括抗肿瘤，抗炎和抗菌活性。
货号:ajcx32750
CAS:526-06-7
分子式:C22H26O6
分子量：386.44
溶解度:DMSO : 100 mg/mL (258.77 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1].

Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80µM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1].

参考文献:
[1]. Ki Hong Nam, et al. Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153.