您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > AA92593
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
AA92593
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AA92593图片
规格:98%
分子量:269.36
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
AA92593 是选择性、竞争性的的 OPN4 (melanopsin) 拮抗剂。
货号:ajcx32770
CAS:457961-34-1
分子式:C13H19NO3S
分子量:269.36
溶解度:DMSO : 250 mg/mL (928.13 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

AA92593 is a selective and competitive OPN4 (melanopsin) antagonist[1][2].

AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression[1].AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins[1].Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo[3].AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells[4].

AA92593 is able to decrease IOP in rabbits living under normal light condition[2].AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2].

参考文献:
[1]. Maria NathÁlia Moraes, et al. Melanopsin, a Canonical Light Receptor, Mediates Thermal Activation of Clock Genes. Sci Rep. 2017 Oct 25;7(1):13977.
[2]. Victoria Eugenia LledÓ, et al. Yellow Filter Effect on Melatonin Secretion in the Eye: Role in IOP Regulation. Curr Eye Res. 2019 Jun;44(6):614-618.
[3]. Gabriel E Bertolesi, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of α-MSH in the pituitary gland. Pigment Cell Melanoma Res. 2015 Sep;28(5):559-71.
[4]. Kenneth A Jones, et al. Small-molecule antagonists of melanopsin-mediated phototransduction. Nat Chem Biol. 2013 Oct;9(10):630-5.