Description: Loxapine Succinate is a potent D2DR/D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. Loxapine 0.2 μM, 2 μM and 20 μM reduces IL-1beta secretion by LPS-activated mixed glia cultures after 1 and 3 days of exposure. Loxapine in concentrations of 0.2 μM, 2 μM and 20 μM reduces IL-2 secretion in mixed glia cultures after 1 and 3 days of exposure, and additionally Loxapine decreases IL-1beta and IL-2 secretion in LPS-induced microglia cultures in concentrations of 2 μM, 10 μM and 20 μM.

References: Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30; Psychiatry Res. 1984 Aug;12(4):277-85.

Related CAS#:27833-64-3 (Succinate); 1977-10-2 (free)

纯度：≥98%

CAS：1977-10-2