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pm26TGF-β1 peptide TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:1506.58
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
pm26TGF-β1 peptide TFA 是一种模拟人 TGF-β1 分子的肽,并对 TGF-β1 受体具有高亲和力。pm26TGF-β1 peptide TFA 具有有效的抗炎特性,并且不表现出嗜中性粒细胞的趋化性。
货号:ajcx32994
CAS:N/A
分子式:C56H94F3N19O22S2
分子量:1506.58
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction[1][2].

The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation[1].

pm26TGF-β1 peptide (100-1000 µg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice[1].

[1]. EmÍlia R Vaz, et al. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116.
[2]. Rodrigues, Tamiris Sabrina. Evaluation of the action of the synthetic peptide pm26TGF-β1, human TGF-β1 mimetic, on TNF-α induced apoptosis in Drosophila melanogaster. Universidade Federal de UberlÂndia, 2017.