JMJD7-IN-1 是一种有效的 JMJD7 抑制剂，IC50 值为 6.62 μM。JMJD7-IN-1 对表达高水平 JMJD7 的细胞显示出良好的抑制活性。
货号:ajcx33056
CAS:311316-96-8
分子式:C16H8Cl2N2O4
分子量：363.15
溶解度:DMSO : 8.33 mg/mL (22.94 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7[1].

JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM[1].JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM[1].JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively[1].

[1]. Zhang W, et, al. Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation. Bioorg Med Chem Lett. 2021 May 25;45:128139.