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CRA-2059 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CRA-2059 hydrochloride图片
规格:98%
分子量:787.27
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
CRA-2059 hydrochloride 是一种特异性、选择性的类胰蛋白酶 (tryptase) 抑制剂,对重组人类胰蛋白酶-β (rHTβ) 的 Ki 为 620 pM。
货号:ajcx33664
CAS:N/A
分子式:C34H47ClN12O8
分子量:787.27
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].

Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 hydrochloride has the potential for inflammatory bowel disease research[1].

[1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413.
[2]. Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611.