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N,N&rsquo-Dinitrosopiperazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N,N&rsquo-Dinitrosopiperazine图片
规格:98%
分子量:144.13
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
N,N’-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 是一种致癌物 (carcinogen),特异性针对鼻咽癌,可促进鼻咽癌的转移。N,N’-Dinitrosopiperazine 通过蛋白磷酸化调节多种信号通路,包括 LYRIC,在丝氨酸 568 位。
货号:ajcx35002
CAS:140-79-4
分子式:C4H8N4O2
分子量:144.13
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N,N’-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N’-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[1].

N,N’-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8 μM concentration range. However, it is cytotoxic from the concentration 10 μM[1].N,N’-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6 μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%[1].N,N’-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells[1].

N,N’-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice[1].

[1]. Damao Huang, et al. Identification of Novel Signaling Components in N,N’-dinitrosopiperazine-mediated Metastasis of Nasopharyngeal Carcinoma by Quantitative Phosphoproteomics. BMC Cancer. 2014 Apr 5;14:243.