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TL-895
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TL-895图片
规格:98%
分子量:447.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
TL-895 是一种有效的,具有口服活性的,ATP 竞争性的,高度选择性不可逆 BTK 抑制剂,其 IC50 和 Ki 值分别为 1.5 nM 和 11.9 nM。TL-895 可用于 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症研究。
货号:ajcx35270
CAS:1415823-49-2
分子式:C25H26FN5O2
分子量:447.5
溶解度:DMSO : 250 mg/mL (558.66 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively[1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research[2][3][4].

[1]. Richard D Caldwell, et al. Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. J Med Chem. 2019 Sep 12;62(17):7643-7655. [2]. Valeria Di Battista, et al. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review. Int J Mol Sci
[3]. A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer
[4]. Study of TL-895 in Subjects With Myelofibrosis