FTX-6058 是一种有效的，具有口服活性的胚胎外胚层发育 (EED) 抑制剂。FTX-6058 可以在细胞和鼠模型中诱导 HbF 蛋白表达。FTX-6058 可用于特定血红蛋白病的研究，包括镰状细胞病和 β-地中海贫血。
货号:ajcx35892
CAS:2490676-18-9
分子式:C22H18FN5O2
分子量：403.41
溶解度:DMSO : 125 mg/mL (309.86 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

FTX-6058 inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].

[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021.
[2]. Fulcrum Therapeutics Presents Published Structure of Investigational Small Molecule FTX-6058 at the American Chemical Society (ACS) Spring 2021 Virtual Conference.