JDQ-443 (example 1a) 是 KRAS G12C 的共价抑制剂。
货号:ajcx35928
CAS:2653994-08-0
分子式:C29H28ClN7O
分子量：526.03
溶解度:DMSO : 250 mg/mL (475.26 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JDQ-443 (example 1a) is a covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1)[1].

JDQ-443 (NVP-JDQ443) traps the GDP-bound inactive conformation of KRAS[1].

[1]. LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1.