您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Bis-PEG9-NHS ester
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bis-PEG9-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG9-NHS ester图片
规格:98%
分子量:708.71
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Bis-PEG9-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG9-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG9-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
货号:ajcx36474
CAS:1008402-79-6
分子式:C30H48N2O17
分子量:708.71
溶解度:DMSO : 100 mg/mL (141.10 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Targeting m2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide. WO2019212324A1