CDK7-IN-2 是一种有效的 CDK7 抑制剂。CDK7 与细胞周期和转录活性的时间控制有关。CDK7 通过 RNA 聚合酶 II (RNAPII) 的 Rbpl 亚基的磷酸化参与转录起始过程。CDK7 具有研究癌症疾病的潜力，特别是侵袭性和难以治疗的癌症 (摘自专利 WO2019099298A1，化合物 1)。
货号:ajcx36736
CAS:2326428-19-5
分子式:C26H39N7O3
分子量：497.63
溶解度:DMSO : 100 mg/mL (200.95 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1)[1].

[1]. David Andrew Coates, et al. Compounds useful for inhibiting cdk7. Patent WO2019099298A1.