(S,R,S)-AHPC-Me-C5-COOH 是一种合成的 E3 连接酶配体结合物，它结合了 VHL 配体和 linker。(S,R,S)-AHPC-Me-C5-COOH 可用于 PROTAC MS432 。
货号:ajcx37486
CAS:2376139-52-3
分子式:C34H53N5O4S
分子量：627.88
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 [1].

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].

[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911.