ABD957 是一种有效和选择性的去棕榈酰酶 ABHD17 家族的共价抑制剂，抑制 IC50 的 IC50 为 0.21 ?M。ABD957 可以阻断 N-Ras 信号传导和 NRAS 突变 AML 细胞的生长。
货号:ajcx37588
CAS:N/A
分子式:C27H36F3N7O5S
分子量：627.68
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells[1].

ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells[1].ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells[1].

[1]. Remsberg JR, et, al. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Aug;17(8):856-864.