Fosnetupitant (Pronetupitant) 是 Netupitant 的亚甲基磷酸前体药物。Fosnetupitant (Pronetupitant) 对人 NK1 受体的 pKi 值为 9.5。
货号:ajcx38148
CAS:1703748-89-3
分子式:C31H35F6N4O5P
分子量：688.6
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].

Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1].

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1].

[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.