(S)-(-)-Levamisole (Levamisole)，一种驱虫剂，具有免疫调节特性的。(S)-(-)-Levamisole 作为 α3β2 (EC50=300 μM) 和 α3β4 (EC50=100 μM) 的正变构调节剂 (PAM) ) nAChRs 的亚型。具有口服活性。
货号:ajcx38194
CAS:14769-73-4
分子式:C11H12N2S
分子量：204.29
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].

(S)-(-)-Levamisole (Levamisole) (50 μg/ml and 200 μg/ml; p.o.; 30 days) prevents weight gain in mice that were fed a high fat diet[2].

[1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. [2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158.