CSF1R-IN-3 (compound 21) 是一种口服有效的 CSF-1R 抑制剂（IC50=2.1nM）。CSF1R-IN-3 是一种有效的抗结直肠癌细胞增殖活性。CSF1R-IN-3 通过抑制巨噬细胞的迁移，将 M2 样巨噬细胞重新编程为 M1 表型，并增强抗肿瘤免疫，从而抑制结直肠癌的进展。
货号:ajcx38330
CAS:2760584-90-3
分子式:C30H38N8O4
分子量：574.67
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].

[1]. Lv Q, et al. Discovery of (Z)-1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021;64(23):17184-17208.