GLUT inhibitor-1 是一种有效且具有口服活性的葡萄糖转运蛋白抑制剂，靶向 GLUT1 和 GLUT3，IC50s 值分别为 242 nM 和 179 nM。GLUT inhibitor-1 具有研究癌症和自身免疫性疾病的潜力。
货号:ajcx38470
CAS:2421141-40-2
分子式:C32H35N7O2
分子量：549.67
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].

Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1]. Parameter Mouse Rat oral C_{max (ng/mL)25251675 oral AUC (ng/mL)58906813 CL (mL/min/kg)4037 Vdss (L/Kg)1.70 4.51 t1/2 (h)0.7852.59 F (%)45.449.4 B/P^{b0.05b: Solubility is determined in PBS buffer solutions.}}

[1]. Liu KG, et al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020;63(10):5201-5211.