SHMT-IN-2 (compound 2) 是一种特异性人SHMT1/2 小分子抑制剂，对 SHMT1 和 SHMT2 的 IC50值分别为 13 nM 和 66 nM。SHMT-IN-2 (compound 2) 可以抑制许多人类癌细胞的生长，对B细胞淋巴瘤有敏感性。
货号:ajcx39076
CAS:2102681-49-0
分子式:C22H24F3N5O
分子量：431.45
溶解度:DMSO : 100 mg/mL (231.78 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SHMT-IN-2 (compound 2) is a stereo specific small-molecule inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (compound 2) can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1].

SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC50 values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (compound 2) shows the growth sensitivity with the median IC50 was 4 μM to a panel of nearly 300 human cancer cell lines (with IC50 values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells[1].

[1]. regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.