Aleplasinin 是一种口服有效的、可透过血脑屏障的、选择性的 SERPINE1 (PAI-1，纤溶酶原激活物抑制剂 -1) 抑制剂。Aleplasinin 增加淀粉样蛋白 -β (Aβ) 分解代谢，改善淀粉样蛋白相关病理。Aleplasinin 可改善记忆缺陷。Aleplasinin 可用于阿尔茨海默病的研究。
货号:ajcx39274
CAS:481629-87-2
分子式:C28H27NO3
分子量：425.52
溶解度:DMSO : 250 mg/mL (587.52 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].

[1]. Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4.
[2]. Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.