Homo-PROTAC pVHL30 degrader 1 是基于 PROTAC 的有效 pVHL30 降解剂。
货号:ajcx39282
CAS:2244684-49-7
分子式:C58H82N8O14S2
分子量：1179.45
溶解度:DMSO : ≥ 150 mg/mL (127.18 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.