GlyT1 Inhibitor 1 是一种有效的选择性 GlyT1 抑制剂，抑制 rGlyT1， IC50 为 38 nM。
货号:ajcx39348
CAS:1820934-93-7
分子式:C22H21N5O2
分子量：387.43
溶解度:DMSO : 25 mg/mL (64.53 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].

GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1].

[1]. Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033.

Protocol:

rGlyT1 38nM(IC50)