DDR1-IN-5 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 7.36 nM。DDR1-IN-5 抑制 DDR1b (Y513) 自磷酸化，IC50 为 4.1 nM。DDR1-IN-5 具有抗癌活性。
货号:ajcx39462
CAS:2416022-90-5
分子式:C22H13F3N6O
分子量：434.37
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].

[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.

Protocol:

DDR1 7.36nM(IC50)