TA-316 (Megakaryocytes/platelets inducing agent) 是一种新的化学合成的 c-MPL 激动剂 (CMA) 和血小板生成素 (TPO) 受体激动剂。TA-316 增强人诱导多能干细胞 (iPS) 血小板的生成。
货号:ajcx39874
CAS:1429321-13-0
分子式:C28H25BrN4O5S2
分子量：641.56
溶解度:DMSO : 50 mg/mL (77.94 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2].

TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively[2].TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers[2].TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression[2].

[1]. METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS.WO2013051625A1.
[2]. Aihara A, et al. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Adv. 2017;1(7):468-476. Published 2017 Feb 28.