A potent and selective human TLR2 antagonist with low cytotoxicity
货号:ajcx11598
CAS:N/A
分子式:C??H??O?.?/?H?O
分子量：310.78
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7?μM for Pam3CSK4-induced hTLR2/1 and 5.7?μM for Pam2CSK4-induced hTLR2/6 responses[1].

MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100?μM) shows no cytotoxic effects up to 100?μM in peripheral blood mononuclear cells (PBMCs)[1].

参考文献:
[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160.