Fidarestat(SNK860)是一种醛糖还原酶(aldosereductase)抑制剂，对aldosereductase，AKR1B10和V301LAKR1B10的IC50值分别为26nM，33μM和1.8μM；Fidarestat(SNK860)具有治疗糖尿病的潜力。
货号:ajcx12572
CAS:136087-85-9
分子式:C12H10FN3O4
分子量：279.22
溶解度:DMSO: 250 mg/mL (895.35 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively[1].

Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats[2].

[1]. Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. [2]. Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9.