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Nucleocidin(4'-Fluoro-5'-O-sulfamoyladenosine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nucleocidin(4'-Fluoro-5'-O-sulfamoyladenosine)图片
规格:98%
分子量:364.31
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Nucleocidin是一种抗生素,抑制标签氨基酸从S-RNA转运到蛋白质的过程。
货号:ajcx13112
CAS:24751-69-7
分子式:C10H13FN6O6S
分子量:364.31
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA[1].


[1]. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8.