LCL521dihydrochloride(1,3DMG-B13dihydrochloride)是一种酸性神经酰胺酶(ACDase)抑制剂。LCL521还抑制溶酶体酸性鞘磷脂酶(ASMase)。
货号:ajcx13134
CAS:1226759-47-2
分子式:C31H54Cl2N4O7
分子量：665.69
溶解度:DMSO : 20.83 mg/mL (31.29 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].

[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.