D8-MMAD是MMAD的氘代形式。
货号:ajcx13836
CAS:N/A
分子式:C41H58D8N6O6S
分子量：779.11
溶解度:DMSO: ≥ 100 mg/mL (128.35 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent. IC50 & Target: Tubulin[1]

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.