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Dehydroaripiprazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dehydroaripiprazole图片
规格:98%
分子量:446.37
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Dehydroaripiprazole (OPC-14857) 是 Aripiprazole 的活性代谢产物。Aripiprazole 是一种抗精神病药,被 CYP3A4 和 CYP2D6 代谢,主要形成 Dehydroaripiprazole。Dehydroaripiprazole 具有与 Aripiprazole 同等的抗精神病活性。
货号:ajcx17142
CAS:129722-25-4
分子式:C23H25Cl2N3O2
分子量:446.37
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].


[1]. Kirschbaum KM, et al. Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects. World J Biol Psychiatry. 2008;9(3):212-8. [2]. Lin SK, et al. Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia. J Clin Psychopharmacol. 2011 Dec;31(6):758-62. [3]. Hui-ChingHuang, et al. Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography-mass spectrometry in blood samples of psychiatric patients. Journal of Chromatography B. Volume 856, Issues 1-2, 1 September 2007, Pages 57-61. [4]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.