您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Pam3CSK4(trifluoroacetate salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Pam3CSK4(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pam3CSK4(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:2123元
分子量:1510.2

产品介绍
Pam3CSK4 is a synthetic bacterial lipopeptide that binds to and acts as an agonist at toll-like receptor 2 (TLR2).
货号:ajcx18828
CAS:N/A
分子式:C81H156N10O13S•XCF3COOH
分子量:1510.2
溶解度:1mg/mL in formic acid
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Pam3CSK4 is a synthetic bacterial lipopeptide that binds to and acts as an agonist at toll-like receptor 2 (TLR2).[1] It induces proliferation of isolated mouse spleen cells and activates lymphocytes at a concentration of 50 μg/ml.[2] Pam3CSK4 is a potent immune adjuvant in mice, enhancing the response to antigen, as measured by IgM and IgG levels, when used at a dose of 200 μg/animal. It inhibits Th1 and Th2 responses, suppresses eosinophil infiltration, and induces CD4+ T cell apoptosis in a mouse model of allergic conjunctivitis.[3] Pam3CSK4 (50 μg) decreases lesion size and parasite burden in genetically-resistant and -susceptible mice when administered with L. major to induce leishmaniasis.[4] It also enhances Th1 responses and stimulates IL-17 production in the early phase of infection.

参考文献:
[1]. Vasselon, T., Detmers, P.A., Charron, D., et al. TLR2 recognizes a bacterial lipopeptide through direct binding. J. Immunol. 173(12), 7401-7405 (2004).
[2]. Reitermann, A., Metzger, J., Wiesmüller, K.H., et al. Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten. Biol. Chem. Hoppe Seyler 370(4), 343-352 (1989).
[3]. Fukushima, A., Yamaguchi, T., Ishida, W., et al. TLR2 agonist ameliorates murine experimental allergic conjunctivitis by inducing CD4 positive T-cell apoptosis rather than by affecting the Th1/Th2 balance. Biochem. Biophys. Res. Commun. 339(4), 1048-1055 (2006).
[4]. Huang, L., Hinchman, M., and Mendez, S. Coinjection with TLR2 agonist Pam3CSK4 reduces the pathology of leishmanization in mice. PLoS Negl. Trop. Dis. 9(3), e0003546 (2015).