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Prolyl-glycyl-proline Peptide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:269.3
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).
货号:ajcx18870
CAS:N/A
分子式:N/A
分子量:269.3
溶解度:Acetic Acid (80%): 50 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade. First, the matrix metalloproteases MMP-8 or MMP-9 cleave collagen to peptides 30-100 amino acids in length. Prolyl endopeptidase further cleaves the collagen fragments to PGP. PGP and the related peptide N-acetylated PGP act through chemokine receptors CXCR1 and CXCR2 on neutrophil cells. Patients with cystic fibrosis have been shown to have elevated levels of PGP peptides in sputum. PGP, but not N-acetylated PGP, has been demonstrated to be a substrate for the pro-inflammatory enzyme LTA4 hydrolase.