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CTOP(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTOP(trifluoroacetate salt)图片
规格:98%
分子量:1062.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
C50H67N11O11S2.XCF3COOH
货号:ajcx19362
CAS:N/A
分子式:C50H67N11O11S2.XCF3COOH
分子量:1062.3
溶解度:Ethanol: slightly soluble,Water: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CTOP is a peptide antagonist of the μ-opioid receptor (IC50 = 2.8 nM).1 It is selective for μ-opioid receptors over δ-opioid receptors (IC50 = 13,500 nM) and somatostatin receptors (IC50 = 24,000 nM). CTOP inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol).2 It also induces withdrawal symptoms in a mouse model of chronic, but not acute, morphine dependence.

参考文献
1. Pelton, J.T., Kazmierski, W., Gluya, K., et al. Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. Journal of Medicinal Chemistry 29(11), 2370-2375 (2013).
2. Gulya, K., KrivÁn, M., Nyolczas, N., et al. Central effects of the potent and highly selective μ opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice. Eur. J. Pharmacol. 150(3), 355-360 (1988).