您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > N&epsilon-(1-Carboxyethyl)-L-lysine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
N&epsilon-(1-Carboxyethyl)-L-lysine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N&epsilon-(1-Carboxyethyl)-L-lysine图片
规格:98%
分子量:218.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
C9H18N2O4
货号:ajcx19558
CAS:5746-03-2
分子式:C9H18N2O4
分子量:218.3
溶解度:Water: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end product (AGE) produced by the reaction of methyl glyoxal with lysine residues in proteins.1 Protein bound, but not free, CEL binds to the receptor for AGEs (RAGE).2 CEL levels are elevated in the lens of diabetic patients with cataract.3 Long-term caloric restriction decreases CEL levels in rat heart mitochondria.4 It decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner when used at a concentration of 1 mM.5

参考文献
1. Ahmed, M.U., Brinkmann, F.E., Degenhardt, T.P., et al. Nε-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem. J. 324(Pt 2), 565-570 (1997).
2. Xue, J., Ray, R., Singer, D., et al. The receptor for advanced glycation end products (RAGE) specifically recognizes methylglyoxal-derived AGEs. Biochemistry 53(20), 3327-3335 (2014).
3. Hashim, Z., and Zarina, S. Advanced glycation end products in diabetic and non-diabetic human subjects suffering from cataract. Age (Dordr) 33(3), 377-384 (2011).
4. Pamplona, R., Portero-OtÍn, M., Bellmunt, M.J., et al. Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins. Free Radic. Res. 36(1), 47-54 (2002).
5. Hansen, F.K., BattÚ, C.E., Dutra, M.F., et al. Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids 48(2), 375-385 (2016).