| 规格: | 98% |
| 分子量: | 509.7 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Amprenavir-d4 is intended for use as an internal standard for the quantification of amprenavir by GC- or LC-MS. Amprenavir is an inhibitor of HIV protease (Ki = 0.04 nM).1 It inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 150 nM). Formulations containing amprenavir have been used in combination with other antiretroviral agents in the treatment of HIV-1 infection.
|1. Sherrill, R.G., Furfine, E.S., Hazen, R.J., et al. Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors. Bioorganic & Medicinal Chemistry Letters 15(15), 3560-3564 (2005).
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