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C24:1 dihydro 1-Deoxyceramide(m18:0/24:1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C24:1 dihydro 1-Deoxyceramide(m18:0/24:1)图片
规格:98%
分子量:634.1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A very long-chain atypical ceramide
货号:ajcx20274
CAS:1246298-60-1
分子式:C42H83NO2
分子量:634.1
溶解度:DMF: 0.5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) is a very long-chain atypical ceramide containing a 1-deoxysphinganine (m18:0) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24:1 dihydro 1-Deoxyceramide (m18:0/24:1) has been found as a major 1-deoxyceramide species in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinanine-d3.3


|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Alecu, I., Tedeschi, A., Behler, N., et al. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid. Res. 58(1), 42-59 (2017).