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13,14-dihydro-16,16-difluoro Prostaglandin J2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
13,14-dihydro-16,16-difluoro Prostaglandin J2图片
规格:98%
分子量:372.5
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21110
CAS:N/A
分子式:C20H30F2O4
分子量:372.5
溶解度:DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin J2(PGJ2) is an analog of PGD2that can inhibit both platelet aggregation and cell growth.1,2,3However, it is not clear whether these effects are initiated by PGJ2or a derivative. 13,14-dihydro-16,16-difluoro PGJ2is an analog of PGJ2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradationin vivo.4Importantly, 13,14-dihydro PGE1has activity that is comparable to that of PGE1, suggesting that this analog of PGJ2could be biologically active.5,6


1.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983) 2.Mahmud, I., Smith, D.L., Whyte, M.A., et al.On the identification and biological properties of prostaglandin J2Prostaglandins Leukot. Med.16(2)131-146(1984) 3.Fukushima, M.Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involvedEicosanoids3(4)189-199(1990) 4.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 5.ÄnggÅrd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 6.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)