A neuropeptide with diverse biological activities
货号:ajcx21124
CAS:N/A
分子式:C20H26D4O4
分子量：338.5
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 2.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

15-deoxy-δ^12,14-Prostaglandin D₂-d₄(15-deoxy-δ^12,14-PGD₂-d₄) is an internal standard for the quantification of 15-deoxy-δ^12,14-PGD₂by GC- or LC-MS. 15-deoxy-δ^12,14-PGD₂is a metabolite of PGD₂.¹It is an agonist of PGD₂receptor 2 (DP₂) that binds DP₂(K_i= 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC₅₀= 8 nM).^2,3It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.¹15-deoxy-δ^12,14-PGD₂is cytotoxic to L1210 murine leukemia cells (IC₅₀= 0.3 µg/ml).⁴It inhibits ADP-induced platelet aggregation (IC₅₀= 320 ng/ml) less potently than PGD₂.⁵

1.SÖderstrÖm, M., Wigren, J., Surapureddi, S., et al.Novel prostaglandin D2-derived activators of peroxisome proliferator-activated receptor-γ are formed in macrophage cell culturesBiochim. Biophys. Acta1631(1)35-41(2003) 2.Hata, A.N., Zent, R., Breyer, M.D., et al.Expression and molecular pharmacology of the mouse CRTH2 receptorJ. Pharmacol. Exp. Ther.306(2)463-470(2003) 3.Monneret, G., Li, H., Vasilescu, J., et al.15-Deoxy-δ12,14-prostaglandins D2 and J2 are potent activators of human eosinophilsJ. Immunol.168(7)3563-3569(2002) 4.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995) 5.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983)