您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 15-deoxy-&delta12,14-Prostaglandin D2-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
15-deoxy-&delta12,14-Prostaglandin D2-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
15-deoxy-&delta12,14-Prostaglandin D2-d4图片
包装:100ug
规格:98%
市场价:4267元
分子量:338.5

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21124
CAS:N/A
分子式:C20H26D4O4
分子量:338.5
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 2.5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

15-deoxy-δ12,14-Prostaglandin D2-d4(15-deoxy-δ12,14-PGD2-d4) is an internal standard for the quantification of 15-deoxy-δ12,14-PGD2by GC- or LC-MS. 15-deoxy-δ12,14-PGD2is a metabolite of PGD2.1It is an agonist of PGD2receptor 2 (DP2) that binds DP2(Ki= 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50= 8 nM).2,3It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.115-deoxy-δ12,14-PGD2is cytotoxic to L1210 murine leukemia cells (IC50= 0.3 µg/ml).4It inhibits ADP-induced platelet aggregation (IC50= 320 ng/ml) less potently than PGD2.5


1.SÖderstrÖm, M., Wigren, J., Surapureddi, S., et al.Novel prostaglandin D2-derived activators of peroxisome proliferator-activated receptor-γ are formed in macrophage cell culturesBiochim. Biophys. Acta1631(1)35-41(2003) 2.Hata, A.N., Zent, R., Breyer, M.D., et al.Expression and molecular pharmacology of the mouse CRTH2 receptorJ. Pharmacol. Exp. Ther.306(2)463-470(2003) 3.Monneret, G., Li, H., Vasilescu, J., et al.15-Deoxy-δ12,14-prostaglandins D2 and J2 are potent activators of human eosinophilsJ. Immunol.168(7)3563-3569(2002) 4.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995) 5.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983)