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Bromfenac-d4(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bromfenac-d4(sodium salt)图片
规格:98%
分子量:360.2
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21848
CAS:N/A
分子式:C15H7BrD4NO3.Na
分子量:360.2
溶解度:DMSO: 100 mM,Ethanol: 5 mM,Water: 100 mM
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bromfenac-d4is intended for use as an internal standard for the quantification of bromfenac by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50= 6.6 nM) that is selective over COX-1 (IC50= 210 nM).1It inhibits prostaglandin E2production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.2Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.


1.Waterbury, L.D., Silliman, D., and Jolas, T.Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodiumCurr. Med. Res. Opin.22(6)1133-1140(2006) 2.Brookshire, H.L., English, R.V., Nadelstein, B., et al.Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removalVet. Ophthalmol.18(3)175-185(2015)