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Chlorothalonil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorothalonil图片
包装:100mg
规格:98%
市场价:433元
分子量:265.9

产品介绍
百菌清是一种广谱杀菌剂,可有效保护植物免受主要由致病疫霉和菌链格孢菌引起的真菌病害。
货号:ajcx22074
CAS:1897-45-6
分子式:C8Cl4N2
分子量:265.9
溶解度:DMSO: Slightly Soluble,Methanol: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively.1In vitro, it inhibits the growth ofC. albicansandC. orbicularefungi,S. aureusandB. cereusGram-positive bacteria, andE. coliandP. aeruginosaGram-negative bacteria (MICs = 0.7, 5, 1.3, 0.7, 0.5, and 1.7 µg/ml, respectively).2,3In vivo, chlorothalonil (100 µg/ml) completely inhibits the growth ofP. infestans, the tomato late blight pathogen, on tomato plants.4It is toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively, as well as to other aquatic invertebrates.5Chlorothalonil is carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats when administered at a dose of 3.8 mg/kg per day, but it is not genotoxic.6Formulations containing chlorothalonil have been used as fungicides in agriculture.


1.Tillman, R.W., Siegel, M.R., and Long, J.W.Mechanism of action and fate of the fungicide chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) in biological systems. I. Reactions with cells and subcellular components of Saccharomyces pastorianusPestic. Biochem. Physiol.3(2)160-167(1973) 2.Shi, L.-P., Jiang, K.-M., Jiang, J.-J., et al.Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivativesBioorg. Med. Chem. Lett.23(21)5958-5963(2013) 3.Lee, J.Y., Moon, S.S., and Hwang, B.K.Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizomePest. Manag. Sci.61(8)821-825(2005) 4.Lee, Y.M., Moon, J.S., Yun, B.-S., et al.Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryiJ. Agric. Food. Chem.57(13)5750-5755(2009) 5.DeLorenzo, M.E., and Fulton, M.H.Comparative risk assessment of permethrin, chlorothalonil, and diuron to coastal aquatic speciesMar. Pollut. Bull.64(7)1291-1299(2012) 6.Wilkinson, C.F., and Killeen, J.C.A mechanistic interpretation of the oncogenicity of chlorothalonil in rodents and an assessment of human relevanceRegul. Toxicol. Pharmacol.24(1 Pt 1)69-84(1996)