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Clarithromycin-13C-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clarithromycin-13C-d3图片
规格:98%
分子量:752
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22100
CAS:N/A
分子式:C37[13C]H66D3NO13
分子量:752
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Clarithromycin-13C-d3is intended for use as an internal standard for the quantification of clarithromycin by GC- or LC-MS. Clarithromycin is a macrolide antibiotic.1,2It is active against pneumococci,Streptococcus,Listeria, andCorynebacterium. Clarithromycin is a group 2 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it exhibits a lower affinity for CYP3A4 than does erythromycin .3,4Formulations containing clarithromycin have been used in the treatment of bacterial infections and, when used in combination with other antibiotics, in the treatment ofH. pylori.


1.Hardy, D.J., Hensey, D.M., Beyer, J.M., et al.Comparative in vitro activities of new 14-, 15-, and 16-membered macrolidesAntimicrob. Agents Chemother.32(11)1710-1719(1988) 2.Wilson, D.N.The A-Z of bacterial translation inhibitorsCrit. Rev. Biochem. Mol. Biol.44(6)393-433(2009) 3.Westphal, J.F.Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: An update focused on clarithromycin, azithromycin and dirithromycinBr. J. Clin. Pharmacol.50(4)285-295(2000) 4.Williams, J.A., Ring, B.J., Cantrell, V.E., et al.Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7Drug Metab. Dispos.30(8)883-891(2002)