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Famotidine-13C-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Famotidine-13C-d3图片
包装:1mg
规格:98%
市场价:6356元
分子量:341.5

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22472
CAS:N/A
分子式:C7[13C]H12D3N7O2S3
分子量:341.5
溶解度:DMF: soluble,DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Famotidine-13C-d3is intended for use as an internal standard for the quantification of famotidine by GC- or LC-MS. Famotidine is a histamine H2receptor antagonist with a Kivalue of 12 nM in fractionated guinea pig cerebral cortex membranes.1It is selective for H2over H1and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).2Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50= 0.6 µM).3It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).3Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).


1.Gajtkowski, G.A., Norris, D.B., Rising, T.J., et al.Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortexNature304(5921)65-67(1983) 2.Kubo, N., Shirakawa, S., Kuno, T., et al.Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assayJpn. J. Pharmacol.43(3)277-282(1987) 3.Nagaya, H., Inatomi, N., and Satoh, H.Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogsJpn. J. Pharmacol.55(4)425-436(1991)