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Fluprostenol isopropyl ester-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fluprostenol isopropyl ester-d4图片
规格:98%
分子量:504.6
包装与价格:
包装价格(元)
50ug电议
100ug电议
500ug电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22512
CAS:N/A
分子式:C26H31D4F3O6
分子量:504.6
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Fluprostenol isopropyl ester-d4is intended for use as an internal standard for the quantification of fluprostenol isopropyl ester by GC- or LC-MS. Fluprostenol isopropyl ester is an analog of prostaglandin Fand an isopropyl ester prodrug form of (+)-fluprostenol .1,2Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50value of 40.2 nM.3Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.2It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.


1.Sorbera, L.A., and CastaÑer, J.TravoprostDrugs Future25(1)41-45(2000) 2.Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al.Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonistJ. Ocul. Pharmacol. Ther.17(5)421-432(2001) 3.Sharif, N.A., Kelly, C.R., Crider, J.Y., et al.Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cellsJ. Ocul. Pharmacol. Ther.19(6)501-515(2003)