A neuropeptide with diverse biological activities
货号:ajcx22526
CAS:N/A
分子式:C26H42N6O12S2.XCF3COOH
分子量：694.8
溶解度:Ethanol: soluble,PBS (pH 7.4): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Foxy-5 is a Wnt5a peptide mimetic with anticancer activity.^1,2It increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells when used at concentrations ranging from 1 to 1,000 µM.¹Foxy-5 (2 mg/kg) reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model.²

1.SÄfholm, A., Leandersson, K., Dejmek, J., et al.A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cellsJ. Biol. Chem.281(5)2740-2749(2006) 2.Canesin, G., Evans-Axelsson, S., Hellsten, R., et al.Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse modelPLoS One12(9)e0184418(2017)