C10H21NO2.HCl
货号:ajcx22620
CAS:2748-02-9
分子式:C10H21NO2.HCl
分子量：223.7
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

H-Leu-OtBu is a leucine ester and an amino acid-containing building block.^1,2It increases phosphorylation of the mTORC1 substrate p70 ribosomal S6 kinase (p70S6K) and inhibits L-[¹⁴C]leucine uptake into HeLa S3 cells endogenously expressing L-type amino acid transporter 1 (LAT1) when used at concentrations of 0.4 and 1 mM, respectively.²H-Leu-OtBu has been used in the synthesis of peptide-based ligands of the neurokinin-1 (NK₁) receptor.¹

1.Millet, R., Goossens, J.-F., Bertrand-Caumont, K., et al.Synthesis and biological evaluation of tripeptide derivatives of Cbz-Gly-Leu-Trp-OBzl(CF3)2 as NK1/NK2 ligandsLett. Pept. Sci.6255-262(1999) 2.Nagamori, S., Wiriyasermkul, P., Okuda, S., et al.Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signalingAmino Acids48(4)1045-1058(2016)