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Misoprostol-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Misoprostol-d5图片
规格:98%
分子量:387.6
包装与价格:
包装价格(元)
50ug电议
100ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22962
CAS:N/A
分子式:C22H33D5O5
分子量:387.6
溶解度:DMF: 100 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1.6 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Misoprostol-d5is intended for use as an internal standard for the quantification of misoprostol by GC- or LC-MS. Misoprostol is an analog of prostaglandin E1and an agonist of the PGE2receptor subtypes EP2and EP3.1,2,3It binds to EP1, EP2, EP3-III, and EP4receptors (Kis = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 μM for all).1Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2and EP3receptors, respectively.3,4It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50= 0.35 μM).2Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED50= 0.31 μg/kg).5Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.


1.Abramovitz, M., Adam, M., Boie, Y., et al.The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogsBiochim. Biophys. Acta1483(2)285-293(2000) 2.Talpain, E., Armstrong, R.A., Coleman, R.A., et al.Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophilsBr. J. Pharmacol.114(7)1459-1465(1995) 3.Savage, M.A., Moummi, C., Karabatsos, P.J., et al.SC-46275: A potent and highly selective agonist at the EP3 receptorProstaglandins Leukot. Essent. Fatty Acids49(6)939-943(1993) 4.Nials, A.T., Coleman, R.A., Hartley, D., et al.AH13205 - a novel selective prostanoid EP2 agonistBr. J. Pharmacol.10224P(1991) 5.Bunce, K.T., Clayton, N.M., Coleman, R.A., et al.GR63799X - a novel prostanoid with selectivity for EP3 receptorsAdv. Prostaglandin Thromboxane Leukot. Res.21(A)379-382(1990)